Introducti Introduction The most prevalent form of the disease, type 2 Diabetes Mellitus is often asymptomatic in the early stages and it may remain undiagnosed for many years.The insulin resistance in the liver leads to failure of the hyperinsulinaemia to suppress the gluconeogenesis, which increases fasting glucose levels and decreases. glycogen storage by the liver in the postprandial phase. Increased glucose production in the liver occurs early in the course of diabetes, and it is likely in skeletal muscles after the onset of the insulin secretory abnormalities and the insulin resistance. Due to the insulin resistance in the adipose tissue and obesity, the free fatty acid (FFA) flux from the adipocytes is increased, which in turn leads to an increase in lipid [very low-density lipoprotein (VLDL) and triglycerides] synthesis in the hepatocytes. Materials and Methods This is a prospective and observational study was conducted in the Department of Biochemistry, Ayaan Institute of Medical Sciences Teaching Hospital & Research Centre. A newly diagnosed type 2 DM patients who attended the Medicine Département were included. Subjects were newly diagnosed type 2 DM patients aged 30 years and above. Patients with gestational DM, steroid-induced DM, thyroid disease or secondary dyslipidemia were excluded from the study. Demographic, clinical and laboratory data were retrieved from the case notes of patients who satisfied the eligibility criteria. Results The study included 160 diabetic patients to evaluate the significance of postprandial dyslipidemia. Patients were categorized based on their glycemic status, lipid profiles, and postprandial lipid levels. Postprandial dyslipidemia, characterized by elevated triglycerides and reduced HDL-C levels, was a significant finding in this study. These abnormalities were more pronounced in patients with poor glycemic control, highlighting the importance of postprandial lipid monitoring and its potential role in managing cardiovascular risk in diabetic patients Conclusion Postprandial dyslipidemia is prevalent among diabetic patients and is significantly associated with poor glycemic control. Monitoring postprandial lipid levels could be essential in managing cardiovascular risk in this population.