Introduction A systemic disease's significant eye symptom is pseudo exfoliation syndrome1. It was Lindberg who while conducting his research paid attention to greyish flakes and fringes at the pupillary border and on anterior lens surface. This was found to be as common in cataract patients as in non-cataractous controls older than 55 years. The phenomenon was observed in 50% of glaucoma patients as well. It was also noticed that this was more prevalent with advancing age. Material and Methods the current study, a cross-sectional assessment of the population, was conducted in a hospital in the Hospital. Every patient 45 years of age or older who visited the OPD over a period of 6 months had an evaluation for PEX and PXG. In all, the data analysis took place for two years. Obtaining consent from the institutional ethics committee was accomplished with each participant. In cases where typical PEX was discovered at the pupil, lens surface, or other intraocular structures, it was considered that PEX was present in the eye. Results Among 80 patients, 50 (62.5%) were aged 70–79 years, 25 (31.25%) were 60–69 years, 4 (5%) were over 80, and 1 (1.25%) was 51–59 years. The mean age was 71.83±5.80 years. Males comprised 56 (70%), and females 24 (30%). Bilateral PXF was found in 60 patients (85.71%, 120 eyes), and unilateral in 20 (14.29%, 20 eyes). Lens involvement occurred in 111 (79.29%) eyes, pupillary in 109 (77.86%), iris in 56 (40%), cornea in 20 (14.29%), and angle in 6 (4.29%). Conclusion PES is an age-related, complex systemic disease and characterized by the progressive accumulation of PXM in all ocular tissue, in addition to other parts of the body such as the heart, liver, kidneys, lungs, cerebral meninges, vessel walls, and skin. Multiple epidemiological, geographic, and environmental factors play roles in its pathogenesis. Also, an association between genetic polymorphisms in the LOX1 gene and the disease is known.