Background: Elective surgeries are a cornerstone of modern healthcare, enabling the treatment of various medical conditions with precision and efficacy. Propofol, a widely used intravenous anesthetic, is favored for its rapid onset and short duration of action. The study aimed to evaluate the effects of magnesium sulphate and clonidine on propofol consumption, hemodynamic stability, and postoperative recovery in patients undergoing elective surgeries under general anesthesia. Materials and Methods This prospective, randomized, double-blind, controlled study was conducted in the Department of Anaesthesia, Shadan Institute of Medical Sciences, Teaching Hospital & Research Centre over a period of 12 months. Group M (Magnesium Sulphate Group): Received intravenous magnesium sulphate 50 mg/kg in 100 mL normal saline over 15 minutes before induction, followed by a maintenance infusion of 15 mg/kg/hr. Group C (Clonidine Group): Received intravenous clonidine 2 µg/kg in 100 mL normal saline over 15 minutes before induction. Group S (Saline Group): Received an equivalent volume of normal saline as a placebo. Results Group M (Magnesium Sulphate) had the lowest total propofol consumption (180.5 ± 25.3 mg) and infusion rate (4.2 ± 0.6 mg/kg/hr). Group C (Clonidine) required a slightly higher amount of propofol (210.4 ± 30.1 mg) and infusion rate (4.8 ± 0.7 mg/kg/hr). Group S (Saline) had the highest propofol consumption (280.6 ± 35.7 mg) and infusion rate (6.5 ± 0.9 mg/kg/hr). At intubation, Group S (Saline) showed a significantly higher HR (90.4 ± 8.2 bpm) compared to Group M (82.3± 7.1 bpm) and Group C (80.5 ± 6.8 bpm) (p < 0.001). At induction, MAP values were similar across the three groups (p = 0.62), indicating that initial blood pressure levels were comparable. At intubation, Group S (94.3 ± 8.6 mmHg) had a significantly higher MAP than Group M (88.4 ± 7.5 mmHg) and Group C (86.7± 7.1 mmHg) (p < 0.001). Conclusion The use of adjunctive medications like magnesium sulphate and clonidine in propofol-based anesthesia offers significant benefits in terms of reduced propofol consumption, improved hemodynamic stability, and enhanced postoperative recovery. BIS monitoring plays a crucial role in optimizing the administration of these agents, ensuring precise titration and minimizing complications.