Introduction: Aeroallergens may trigger symptoms in sensitized children with asthma. Documentation of sensitization is crucial to enable effective implementation of measures to prevent asthma exacerbations. To document the sensitization patterns of very young children (≤2 years) with asthma. This study was conducted in view of the crucial importance of aeroallergens in childhood. The purpose of this study was to determine the prevalence of sensitization to common aeroallergens in children with residing in our region and to elucidate the association of aeroallergen sensitization with severity. Methods: This study was conducted at a tertiary care center in northern India. We are following a cohort of pediatric asthma patients (up to 18 yrs) from the Pediatric Chest Clinic since August 2009. Eligibility criteria were children with asthma who stayed in Delhi and nearby areas and willing to follow up 3 monthly regularly for at least 1 year. The diagnosis and treatment of asthma was based on the Global Initiative for Asthma (GINA) guidelines. At enrolment, baseline data was collected, spirometry was performed [6], and FENO measurement was done. Asthma was classified as per the NAEPP guidelines [8]. The patients were followed up every 3 months, symptom diary was maintained, and control was assessed as per GINA guidelines. The cohort included 243 asthmatic children. Results: Children with recurrent (4 or more episodes of wheezing in the past year) ages between 2yrs to 10 yrs. The total number of the patients included in the study was 120 patients, 60 (50%) male and 60 (50%) with Mean Age = 6.15 years. Out of the 60 male cases, 45 (75%) had positive SPT to at least one of the aeroallergens and 15 (25%) were negative for all aeroallergens tested. Out of the 60 female cases, 42(70%) had a positive SPT to at least one of the aeroallergens and 18(30%) were negative for all aeroallergens. Out of 120 children, 87 (87.5%) had positive SPT to at least one of the aeroallergens. The highest prevalence of positive skin reaction was recorded for mite allergens among them Dermatophytosis pteronyssinus (80.6%), D. farinae (80.7%), Bloomia (68.7%), among Fungi group, Aspergillus fumigates (11.9%) Alternaria alternate (10.5%), Cladosporium herbarum (2.8%) Cat, cockroach and pigeon showed positive in (19.5%) (14.9%) and (4.4%) of cases respectively. Among Pollen group Cynodon dactyl (8.9) & Parthenium hysterophorus (7.4) The frequency of positive tests to an individual allergen is depicted in the table (8). In the studied population, the highest a prevalence of positive skin reactions was documented for the D. pteronyssinus and D. farinae with a frequency of (80.5%) of cases, and the lowest for Dog. Conclusion: SPT is an effective way to determine aeroallergen with minimal expense & greater selection of antigen. Specific allergen identification helps in implementing specific allergen preventive measures. Dust mites are the most common aeroallergen in all age groups. Among Dust Mites Dermatophagoides Farinae, Dermatophagoides pteronyssiuns & Blomia are most common. Incidence of aero allergy in children with recurrent wheeze increases with age. Indoor allergens are more common than outdoor allergens.